A report of the results of clinical study of the biologically active peptide bioregulator of bone marrow origin:

Biologically active food supplement Nature’s Marvels Bone Marrow Bioregulator contains a complex of low molecular weight peptides with a molecular weight of up to 5000 Da, extracted from bone marrow tissue of young animals – calves not older than 12 months of age or pigs.

Bone Marrow Bioregulator (Nature’s Marvels™) is available in capsules with an active substance content of 10 mg.

Bone Marrow peptides regulate metabolic processes in the cells of the hematopoietic system, increase its reserve capabilities, have a beneficial effect on the adaptation processes of the body in extreme conditions, and have antioxidant properties regulating the processes of peroxidation in the cells of the hematopoietic system. Experimental studies have shown that peptides have a tissue specific effect on the cells of those tissues from which they are isolated. This allows us to assume the effectiveness of the use of Bone Marrow Bioregulator for restoring the functions of the hematopoietic system in the case of its disorders of various origins, primarily in anemia.

Anemia is not an independent disease, but it occurs as a syndrome in a number of diseases that can either be associated with a primary injury of the blood system or not depend on it. Therefore, anemia is a widespread condition that requires targeted treatment, as the quality of life of people with anemia is drastically reduced.

Any anemia leads to a decrease in the respiratory function of the blood and the development of oxygen starvation of tissues, which is most often expressed by such symptoms as pallor of the skin, increased fatigue, weakness, headaches, dizziness, rapid heartbeat, shortness of breath and others. A decrease in hemoglobin concentration in the blood often occurs with a simultaneous reduction in the number of red blood cells and their qualitative composition changes. In this case, it is essential to preserve the ability of the bone marrow to regenerate, which is manifested by an increase in the number of reticulocytes (young erythrocytes) in the peripheral blood (the norm is 0.5% -2%). Maintaining the regenerative activity of the bone marrow helps to level the symptoms of anemia and improve the patient’s general condition.

In general, the treatment tactics depend on the type of anemia and the severity of the patient’s condition. Currently, vitamin B12 and iron supplements are mainly used to treat anemia. Also, with a low hemoglobin level, red blood cell transfusions can be performed.

Clinical characteristics of patients

A clinical study of the efficacy of Bone Marrow Bioregulator (Nature’s Marvels™) took place at the Medical Center of the Saint Petersburg Institute of Bioregulation and Gerontology of the Northwest Branch of the Russian Academy of Medical Sciences from April to November 2011.

The clinical study involved 26 women aged 35 to 56 years with signs of mild to moderate iron deficiency anemia due to malnutrition. Patients complained of weakness, rapid fatigue, general malaise, decreased concentration, shortness of breath after light or moderate physical activity, palpitations, headache, tinnitus, sleep, and appetite disturbances.

An objective examination revealed pallor of the skin of visible mucous membranes and nail beds, as well as the appearance of functional systolic murmurs in most patients. During laboratory examinations, the patients showed a decrease in the hemoglobin content in the blood to a level of 70-90 g/l, which indicates the presence of mild or moderate anemia.

All patients were divided into 2 groups. Patients in the control group (11 people) received conventional therapy, including iron supplements, vitamin B12, and a special diet. In addition to conventional treatment, patients of the primary group (15 people) received Bone Marrow Bioregulator (Nature’s Marvels™) 1 capsule 2 times a day with meals for 30 days.

Research Methods

We assessed the patients’ complaints and conducted general clinical blood tests during the study.

Research Results

The use of Bone Marrow Bioregulator in patients with mild and moderate anaemia improved the general condition, Bone Marrow Bioregulator which was manifested in a decrease in weakness, rapid fatigue, general malaise, and shortness of breath after light or moderate physical activity. The drug’s effect also decreased palpitations, headaches, tinnitus, sleep disturbances, appetite, and increased concentration and performance (Table 1). It is important to note that the improvement in the condition of patients of the primary group occurred in a shorter time than in the control group, which used only conventional therapy. If in the patients of the control group, the improvement in the condition occurred on average after 35.6 ± 2.7 days, then in the patients of the primary group – after 26.2 ± 1.6 days. Thus, the time of improvement in patients with anaemia with the use of Bone Marrow Bioregulator, in addition to conventional therapy, was reduced by 24.4%

Dynamics of subjective indicators in patients with anaemia

* p <0.05 reliable in comparison with the indicator in patients before treatment;
# p <0.05 reliable in comparison with the indicator in patients after treatment with conventional means.

Effect of Bone Marrow Bioregulator on the content of erythrocytes and hemoglobin in the blood serum of patients with anemia:

* p <0.05 –reliable in comparison with the indicator in patients of the control group.
# p <0.05 –reliable in comparison with the indicator in patients of the control group.

In the laboratory study, after the use of Bone Marrow Bioregulator , a significant improvement in the parametersof the content of erythrocytes and hemoglobin in the blood was noted. As expected, it was more pronounced than the indicators in the patients of the control group (Table 2).
The noted changes in the parameters in the peripheral blood of patients while taking Bone Marrow Bioregulator correlate with clinical indicators. They indicate the restoration of an adequate response of the body’s hematopoietic system in response to malnutrition.

Analysis of the data allows us to conclude that Bone Marrow Bioregulator has a normalizing effect on cellular metabolism in the tissues of the bone marrow, helps restore the functions of the hematopoietic system in women with alimentary anemia. Thus, the results obtained indicate the therapeutic efficacy of Bone Marrow Bioregulator and the practicality of its use in the complex treatment of patients of different ages with anemia of various origins.

When using Bone Marrow Bioregulator (Nature’s Marvels™), no side effects, complications, or drug dependence have been identified.

Bone Marrow Bioregulator (Nature’s Marvels™) can be used for therapeutic and prophylactic purposes in the form of a biologically active food supplement combined with any means of symptomatic and pathogenetic therapy used to treat anemia of various origins.

Conclusion

Biologically active food supplement Bone Marrow Bioregulator (Nature’s Marvels™) has a normalizing effect on the functional activity of bone marrow cells.

Bone Marrow Bioregulator (Nature’s Marvels™) is well tolerated when taken orally, has no side effects, and can be used for therapeutic and prophylactic purposes as a biologically active food supplement. Bone Marrow Bioregulator (Nature’s Marvels™) is recommended for use to patients with anemia of various origins orally during meals, 1-2 capsules 2 times a day for 30 days.

It is recommended to repeat the course of treatment after 3-6 months.

References

1. Belousov Y.B., Moiseev V.S., Lepakhin V.K. Clinical Pharmacology and Pharmacotherapy: A Guide
for Physicians. – M .: the Universe, 1993 .– 398 p.
2. Mashkovsky M.D., Medicines: Pharmacotherapy for doctors, manual: 2 parts. – Vilnius: ZAO “Gamta”,
1993.
3. Geriatric manual / Ed. D.F. Chebotarev, N.B. Mankovsky. – M.: Medicine, 1982. – 544 p.
4. Pogorelov V.M., Kozinets G.I., Kovaleva L.G. Laboratory and clinical diagnostics of anemia. – M.,
2004 .– 172 p.
5. Shiffman F.D. Clinical approach to patients with hematological profile. – In the book: Blood
pathophysiology. – SPb., 2001 .– S. 43-71.

Recommendations For Use

Bone Marrow Bioregulator (Nature’s Marvels™) is a complex of peptides obtained from the bone marrow of young animals. The extracted peptides have a selective effect on bone marrow cells, normalize metabolism in bone marrow cells, and regulate the functions of the hematopoietic system.
Clinical studies established the effectiveness of Bone Marrow Bioregulator (Nature’s Marvels™) in the complex treatment of patients with anemia of various origins when exposed to extreme environmental factors, malnutrition, and the use of diets to reduce weight.

Bone Marrow Bioregulator (Nature’s Marvels™)  instructions: 1-2 capsules or tablets 1-2 times a day with meals. The duration of administration is 30 days. It is advisable to repeat the course in 3-6 months. Do not use if: you suffer from individual intolerance to the components, pregnancy, breastfeeding.

There were no side effects noticed when using Bone Marrow Bioregulator (Nature’s Marvels™) .

Store in a dry, dark place at a temperature from +2 to +25 ºС.

Release form: 20 capsules or tablets containing 10 mg of Bone Marrow Bioregulator (Nature’s Marvels™) .
Expiration date: 3 years from the date of manufacture.